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[barriger]

When deciding between prioritizing the Abhorrent Heart and other Lair Keys in Diablo 4, it’s essential to consider their unique roles, farming methods, and how they impact your progression through Greater Lair bosses and endgame content.

The Abhorrent Hearts is specifically tied to unlocking the Harbinger of Hatred’s Hoard in the Harbinger’s Den. This hoard provides valuable Mythic Uniques, crafting materials, and experience, making the hearts vital for players targeting high-level loot and strong progression. Since three Abhorrent Hearts are required to access this hoard, the farming process—centered around defeating Urivar and using Judicator's Masks—is straightforward and rewarding, especially for players focusing on efficient endgame gearing.

In contrast, other Lair Keys unlock different Greater Lair bosses, each with their own unique rewards, challenge mechanics, and farming routes. Some keys may be easier to farm due to more accessible locations or faster methods, while others could grant highly desirable items or crafting materials specific to your build or playstyle. Prioritizing these keys depends heavily on your current gear needs, character class, and the scalability of the bosses relative to your power level.

From a strategic standpoint, the Abhorrent Heart should be prioritized if you are aiming to enhance your loot pool with high-value rewards from the Harbinger of Hatred, especially if you farm in the Undercity of Kurast where the heart drops are stable and relatively efficient. Players earlier in progression or focusing on different builds might benefit from farming keys linked to other lairs that provide complementary upgrades or easier farming loops.

Another factor is the difficulty and time investment associated with farming. The Abhorrent Heart’s associated farming cycle is well-established with clear routes and objectives, while other Lair Keys may require more exploration or complex conditions to farm efficiently. Evaluating your available playtime and building a farming strategy around the fastest and most rewarding keys is critical for effective progression.

Prioritize Abhorrent Hearts if your goal is to unlock the high-level, rewarding Harbinger of Hatred’s Hoard and you have efficient access to Urivar’s Hoard via the Undercity of Kurast.

Consider other Lair Keys if they unlock bosses that tailor better to your build, drop specific desired gear, or offer faster farming routes aligned with your current power level.

Balance farming time, difficulty, and reward quality based on your current progression stage and goals.

Efficient farming plans often involve cycling through multiple keys depending on evolving needs and seasonal changes to loot tables.

Abhorrent Hearts stand out due to their direct connection to some of the richest endgame rewards, making them a top priority for players seeking to maximize their Diablo 4 run’s efficiency and loot quality. However, flexibility in farming several keys concurrently will yield a more rounded and adaptable character progression path.